Yes, you may be able to by following these steps and using the diagram below.
Go to the Dopamine/COMT Gene page in your report. Look at the table at the bottom of the notable variation blue side-bar on the right hand side of the page.
- Do you have call information for both rs6269 and rs4680?
If no, then unfortunately there is no way to “guess-timate” your likely haplotype.
If yes, you do have results for both SNPs, you are in luck. Look at the diagram below and find the pattern that matches your information.
- Within the table look at rs6269 and determine the first of the two call letters (not the variant allele) you have in your table (it will be either an A or G), then look at rs4680 In your report and determine the first of the two CALL letters (it will also be either an A or G). Take that two letter pairing (the letter from rs6269 comes first, and rs4680 is last) and check against the table to find your speed based on genotype.
- Now repeat the process again, but this time focus on the second letter in each SNP. If you are homozygous for both SNPs, it will be the same combination as the first, and you have TWO copies of the same determined speed. However if you are heterozygous for one or both SNPs it will result in a different letter combination. Now check the table for that new pairing and determine the speed for the new combination. The potential pairings range from a) two copies of high, b) one copy each fast/Intermediate, c) two intermediate copies, d) one copy each Intermediate/slow, e) two copies of slow, and f) most rare: one copy of unknown/with another known speed OR two copies unknown speed.
- As you may now see, the haplotype represents a gradient with speeds decreasing as you move down from two copies of fast to two copies of slow. Unfortunately there is no research to predict speed for those who possess the “unknown” combination, as so few people appear to inherit this combination.
Suppose you have listed in your report rs6269 AG and rs4680 AG.
You have one copy AA (pairing the first letter from each SNP) and one copy GG (pairing the second letter from each SNP). AA corresponds to one copy of the intermediate combination and GG corresponds to one copy of the fast combination. You likely are on the fast end of the COMT activity spectrum. But, don’t forget your lifestyle and environment play a strong role as well.