Time and dose -dependent is aka dose–response relationship, or exposure–response relationship. It describes the biochemical change in activity of an enzyme caused by differing levels of exposures (or doses) to a system after a defined exposure time. This relationship in rarely linear. A dose or exposure might up-regulate in a short time frame, but over time the overall activity eventually deceases. This phenomenon can be influenced by habituation/desensitization in the case of neurotransmitters or some medications. It is also related to hormesis, which is the process of a beneficial effect from exposure to low doses of an agent that, in larger doses, is otherwise toxic or lethal when given at higher doses.
Articles in this section
- Why Doesn’t StrateGene Offer More Personalized Supplement and Dosage Suggestions (when Other Companies Do?)
- Why aren't there more precise, individualized recommendations based on genotype for each SNP?
- Why does my report sometimes have factors that slow or speed up genes, like COMT and CYP1A2, but other genes only have factors that clean and dirty them?
- What is the difference between a pharmacological dose and a physiological dose?
- Which products support each StrateGene Pathway?
- What does high estradiol mean?
- I see some commonly mentioned treatments on the internet are not included in StrateGene treatment considerations. Why is this?
- What does time and dose -dependent and habituation mean?
- Why is synthetic folic acid a bad thing?
- What is heme? What are Porphyria or Pyrrole disorders?