This simply refers to the fact that the mutation's effect must be considered in the appropriate context or on a case by case basis. For example, the GST and SULT mutations affect the substrate binding site changing how it can fit with other chemicals. That fit may be more difficult or easier depending on the shape/conformation of the molecule it is trying to bind with for enzymatic processing. Therefore some compounds will get processed faster, while others will be slower.
Articles in this section
- What Do The Speed Colors On My StrateGene Report Mean?
- A gene on my StrateGene pathway is a single speed/color, however there are multiple SNPs on that gene with different speeds/colors. How do I know how fast or slow the enzyme is naturally?
- What is the difference between the ambiguous (yin yang symbol), question mark, and "complicated" indications on my StrateGene Report?
- Where Can I Find the StrateGene Glossary?
- What do the simultaneous up and down arrows mean in the Summary Tables?
- How exact is the information regarding "change" to kinetics due to a SNP?