Even a "normal" gene can express altered enzyme activity. Look at the regulatory factors for that gene: Perhaps your patient has heavy metal toxicity, lack of cofactors, chronic infection, etc that are affecting the gene, even in lieu of a SNP. Another factor to consider in the clinical evaluation of gene performance is to look at the weight of epigenetic control factors.
Articles in this section
- Why Doesn’t StrateGene Report on APOE SNPs?
- My notable variation for a haplotype says "indeterminate" - what does this mean?
- How come the StrateGene SNP list is so different from what I am reading elsewhere online?
- How accurate are the COMT Haplotype speeds?
- How important is MAT1A in the SAM/methionine story?
- My COMT speed (specifically V158M/RS4680) was different in a previous StrateGene report than what is being reported here in my new StrateGene. Why is this?
- What does “increased risk” mean?
- How can I find more information about a particular SNP?
- I see results reported as NA, NC, or "indeterminate". What does this mean?
- What is meant by "tag SNP"?
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