Constant pathway support is always needed, but not always by using a supplement, and if so, in varying amounts according to Dr Lynch. It all depends on what other environmental, lifestyle, diet, or genetic factors are pushing on your pathways or if they are lacking in some areas. StrateGene is a great genetic analysis tool for seeing which pathways need support (genetically), however a review of your current environmental factors and lifestyle can be addressed by your healthcare professional to get a full picture.
Keep in mind that glutathione supplementation is meant to be pulsed as explained in Dr Lynch's book, Dirty Genes. This is an incredibly important section to read.
Note: Remember to make sure you're staying hydrated to help support your pathways naturally. If you are using Optimal Liposomal Glutathione Plus,you are supporting many pathways, including the sulfite pathway, the cysteine pathway, and the glutathione recycling and utilization pathway, so take extra care in making sure your fully hydrated.