What is Lithium Orotate derived from? Amber Larsen April 11, 2017 20:51 Updated Follow Lithium Orotate is synthetically derived in a laboratory via the bonding of orotic acid and the alkali metal, lithium. Related articles Is Lithium Orotate safe to use while pregnant or breastfeeding? Are there any side-effects or precautions when using Lithium Orotate? Can Lithium Orotate be used for children? Does Adeno B12 contain sulfur? Comments 0 comments Article is closed for comments.