There has been no significant evidence suggesting that it is necessary to cycle on and off of 5-HTP supplements, provided they are being taken at an appropriate dose. If you have any questions or concerns about 5-HTP or cycling the supplement, we recommend that you consult with a naturopath or healthcare professional who is qualified to address your health concerns.
Individuals using SSRI's, MAO inhibitors, antidepressants, migraine drugs, or medications for Parkinson's disease while taking 5-HTP may develop "serotonin syndrome" - an excess amount of serotonin which is associated with symptoms such as confusion, rapid heart rate, sweating, high blood pressure and other potentially negative side effects. These individuals should be especially careful with 5-HTP and should consult with a healthcare professional prior to using 5-HTP supplements.*