MTHFR and acetylcholine are associated due to the folate/choline relationship.
Folate and choline are used heavily as methyl donors within the methylation pathway. If the body does not have enough folate, it will use choline instead. Thus, low folate reduces the amount of choline. If the body does not have enough choline, it will use folate instead. Thus, low choline reduces the amount of folate. However, not all things requiring folate can use choline, and not all things requiring choline can use folate.
MTHFR is an enzyme that provides the folate used in the methylation pathway. If the MTHFR enzyme does not provide the methylation pathway sufficient folate, then the methylation pathway requires more choline.
Those with significant MTHFR genetic variations are more susceptible to low choline. Individuals with the following MTHFR genetic variations may benefit from Optimal Focus†
- homozygous MTHFR C677T
- compound heterozygous MTHFR C677T and MTHFR A1298
- homozygous MTHFR A1298C
Those with any of the above MTHFR genetic variations are especially susceptible to low choline if they don’t:
- eat meat or leafy green vegetables, or
- supplement with folate or choline†.
Optimal Focus† offers two types of highly bioavailable choline, AlphaSize® Alpha GPC and citicoline. †
†These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.